Article

Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> To advance genetic understanding of inflammatory bowel disease (IBD), we conducted genome-wide association meta-analyses of 63,415 IBD cases of European and East Asian descendants and identified 90 previously unknown risk loci. Integrating multi-ancestry transcriptome-wide association studies (TWAS), cell type–specific TWAS, alternative splicing (AS-WAS), and alternative polyadenylation (APA-WAS...

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Literature Corpus work: d6ab309b-0547-5433-87a2-72b18a323985
DOI: 10.1101/2025.09.23.25336483

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