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Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders.

Molecular psychiatry - 1 Jun 2022

Chen Jingqi, Song Liting, Yang Anyi, Dong Guiying, Zhao Xing-Ming

Abstract excerpt

Neurological and psychiatric disorders have overlapped phenotypic profiles, but the underlying tissue-specific functional processes remain largely unknown. In this study, we explore the shared tissue-specificity among 14 neuropsychiatric disorders through the disrupted long-range gene regulations by GWAS-identified regulatory SNPs. Through Hi-C interactions, averagely 38.0% and 17.2% of the intergenic regulatory...

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Brain
Gene Expression Regulation
Gene Regulatory Networks
Neurodevelopmental Disorders
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35379909
DOI: 10.1038/s41380-022-01529-3

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