Article
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease.
Communications biology - 20 Jan 2022
Uellendahl-Werth Florian, Maj Carlo, Borisov Oleg, Juzenas Simonas, Wacker Eike Matthias, Jørgensen Isabella Friis, Steiert Tim Alexander, Bej Saptarshi, Krawitz Peter, Hoffmann Per, Schramm Christoph, Wolkenhauer Olaf, Banasik Karina, Brunak Søren, Schreiber Stefan, Karlsen Tom Hemming, Degenhardt Franziska, Nöthen Markus, Franke Andre, Folseraas Trine, Ellinghaus David
Abstract excerpt
Genetic correlations and an increased incidence of psychiatric disorders in inflammatory-bowel disease have been reported, but shared molecular mechanisms are unknown. We performed cross-tissue and multiple-gene conditioned transcriptome-wide association studies for 23 tissues of the gut-brain-axis using genome-wide association studies data sets (total 180,592 patients) for Crohn's disease, ulcerative colitis,...
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