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Article

Molecular mechanisms of antibody somatic hypermutation.

Annual review of biochemistry - 1 Jan 2007

Di Noia Javier M, Neuberger Michael S

Abstract excerpt

Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation of single nucleotide substitutions into the V gene, underpinning much of antibody diversity and affinity maturation. Hypermutation is triggered by activation-induced deaminase (AID), an enzyme which catalyzes targeted deamination of deoxycytidine residues...

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Source

Identifiers

PMID: 17328676
DOI: 10.1146/annurev.biochem.76.061705.090740

Genes

MSH2
MSH6
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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