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Article

Somatic mutation patterns at Ig and Non-Ig Loci.

DNA repair - 1 Jan 2024

Steele Edward J, Franklin Andrew, Lindley Robyn A

Abstract excerpt

The reverse transcriptase (RT) model of immunoglobulin (Ig) somatic hypermutation (SHM) has received insufficient scientific attention. This is understandable given that DNA deamination mediated by activation-induced deaminase (AID), the initiating step of Ig SHM, has dominated experiments since 2002. We summarise some key history of the RT Ig SHM model dating to 1987. For example, it is now established that DNA...

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Identifiers

PMID: 38056368
DOI: 10.1016/j.dnarep.2023.103607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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