Article
AID in Antibody Diversification: There and Back Again.
Trends in immunology - 1 Jul 2020
Feng Yuqing, Seija Noé, Di Noia Javier M, Martin Alberto
Abstract excerpt
Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation (SHM) and class switch recombination (CSR). AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we review the current understanding of AID function. We discuss AID...
Topics
- Antibody Diversity
- Cytidine Deaminase
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Class Switching
- Mutation
- AICDA (Activation-Induced Cytidine Deaminase)