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Article

DNA flexibility can shape the preferential hypermutation of antibody genes.

Trends in immunology - 1 Mar 2024

Wang Yanyan, Meng Fei-Long, Yeap Leng-Siew

Abstract excerpt

Antibody-coding genes accumulate somatic mutations to achieve antibody affinity maturation. Genetic dissection using various mouse models has shown that intrinsic hypermutations occur preferentially and are predisposed in the DNA region encoding antigen-contacting residues. The molecular basis of nonrandom/preferential mutations is a long-sought question in the field. Here, we summarize recent findings on how...

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Identifiers

PMID: 38402044
DOI: 10.1016/j.it.2024.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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