Article

Deep learning model of somatic hypermutation reveals importance of sequence context beyond targeting of AID and Polη hotspots

2021-08-05

Abstract excerpt

<h4>Summary</h4> B-cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U preferentially targeting WR C (W=A/T, R=A/G) hotspots. Downstream mutations at W A Polymerase η hotspots contribute further mutations. Computational models of SHM can describe the probabil...

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Literature Corpus work: 11ee9ab4-29fa-5aef-88ec-491d979f2912
DOI: 10.1101/2021.08.03.453264

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