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AID–RNA polymerase II transcription-dependent deamination of IgV DNA

14 Sept 2019

Abstract excerpt

Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) in immunoglobulin variable (IgV) genes to produce high-affinity antibodies. SHM requires IgV transcription by RNA polymerase II (Pol II). A eukaryotic transcription system including AID has not been reported previously. Here, we reconstitute AID-catalyzed deamination during Pol II transcription elongation in conjunction with...

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PMID: 31566237
DOI: 10.1093/nar/gkz821

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