Article
DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.
Science immunology - 31 Mar 2023
Hao Qian, Zhan Chuanzong, Lian Chaoyang, Luo Simin, Cao Wenyi, Wang Binbin, Xie Xia, Ye Xiaofei, Gui Tuantuan, Voena Claudia, Pighi Chiara, Wang Yanyan, Tian Ying, Wang Xin, Dai Pengfei, Cai Yanni, Liu Xiaojing, Ouyang Shengqun, Sun Shiqi, Hu Qianwen, Liu Jun, Ye Youqiong, Zhao Jingkun, Lu Aiguo, Wang Ji-Yang, Huang Chuanxin, Su Bing, Meng Fei-Long, Chiarle Roberto, Pan-Hammarström Qiang, Yeap Leng-Siew
Abstract excerpt
Insertions and deletions (indels) are low-frequency deleterious genomic DNA alterations. Despite their rarity, indels are common, and insertions leading to long complementarity-determining region 3 (CDR3) are vital for antigen-binding functions in broadly neutralizing and polyreactive antibodies targeting viruses. Because of challenges in detecting indels, the mechanism that generates indels during immunoglobulin...
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