Article

Structural Modeling of <i>γ</i> -Secretase A <i> β <sub>n</sub> </i> Complex Formation and Substrate Processing

2018-12-19

Abstract excerpt

The intra-membrane aspartyl protease γ -secretase (GSEC) cleaves single-span transmembrane helices including the C-terminal fragment of the amyloid precursor protein (APP). This substrate is initially cleaved at the ɛ-site followed by successive processing (trimming) events mostly in steps of three amino acids. GSEC is responsible for the formation of N -terminal APP amyloid- β (A β ) peptides of different len...

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Literature Corpus work: 97b9770e-b31a-5ea6-a91f-db3f0bbe84fd
DOI: 10.1101/500488

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