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Article

An atomic structure of human γ-secretase.

Nature - 10 Sept 2015

Bai Xiao-Chen, Yan Chuangye, Yang Guanghui, Lu Peilong, Ma Dan, Sun Linfeng, Zhou Rui, Scheres Sjors H W, Shi Yigong

Abstract excerpt

Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-electron microscopy. Mutations derived from Alzheimer's disease affect residues at two hotspots in PS1,...

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Identifiers

PMID: 26280335
DOI: 10.1038/nature14892
PMCID: PMC4568306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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