Mechanisms of γ-Secretase Activation and Substrate Processing

Abstract excerpt

Amyloid β-peptide, the principal component of characteristic cerebral plaques of Alzheimer’s disease (AD), is produced through intramembrane proteolysis of the amyloid precursor protein (APP) by γ-secretase. Despite the importance in pathogenesis of AD, the mechanisms of intramembrane proteolysis and substrate processing by γ-secretase remain poorly understood. Here, complementary all-atom simulations using a robu...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases
• Computational Drug Discovery Methods
• Mutation
• Presenilin-1
• Protein Structure and Dynamics

Identifiers and source

Literature Corpus work

bf91b20b-226a-5f26-911d-92495a466b83

DOI

10.1101/2020.03.09.984534