Article

Membrane dynamics of Notch-bound γ-secretase produces two distinct Notch conformations

2019-04-12

Abstract excerpt

Cleavage of Notch by the major intramembrane aspartyl protease complex γ-secretase is a central event in cell regulation and is also important to Alzheimer’s disease, with more than 200 mutations in the catalytic subunit of γ-secretase (PS1) causing severe early-onset forms of the disease. Recently, cryogenic electron microscopy (cryo-EM) has revealed the electron density of the protein-Notch complex in frozen sol...

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Literature Corpus work: 792e3acb-9ce7-5291-8a14-8b749d4df3da
DOI: 10.1101/607846

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