Article

Presenilin homologues influence substrate binding and processing by γ-secretase: a molecular simulation study

2023-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Presenilin homologues in the γ-secretase complex play a pivotal role in substrate binding and processing, impacting β-amyloid (Aβ) peptide generation in Alzheimer’s disease. We conducted a molecular simulation study to determine substrate preferences between presenilin-1 (PS1) and presenilin-2 (PS2) γ-secretase enzymes for amyloid precursor protein (APP) and Notch1 processing. Using homology mod...

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Literature Corpus work: a944456f-ae15-5bb4-ad00-ef98306b0dde
DOI: 10.1101/2023.05.17.541079

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