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Article

Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase.

Journal of molecular biology - 15 Sept 2023

Ortner Martin, Guschtschin-Schmidt Nadja, Stelzer Walter, Muhle-Goll Claudia, Langosch Dieter

Abstract excerpt

The intramembrane protease γ-secretase activates important signaling molecules, such as Notch receptors. It is still unclear, however, how different elements within the primary structure of substrate transmembrane domains (TMDs) contribute to their cleavability. Using a newly developed yeast-based cleavage assay, we identified three crucial regions within the TMDs of the paralogs Notch1 and Notch3 by mutational...

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Identifiers

PMID: 37536392
DOI: 10.1016/j.jmb.2023.168218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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