Article

Mechanism of Tripeptide Trimming by γ-Secretase

2021-08-05

Abstract excerpt

The membrane-embedded γ-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to produce 37-to-43-residue amyloid β-peptides (Aβ) of Alzheimer’s disease (AD). Despite its importance in pathogenesis, the mechanism of processive proteolysis by γ-secretase remains poorly understood. Here, mass spectrometry and western blotting were used to quantify the efficiency of...

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Literature Corpus work: 2149d066-3d40-5456-9b5f-228243c89065
DOI: 10.1101/2021.08.05.455243

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