Article

Uncovering the Binding Mode of <i>γ</i> -Secretase Inhibitors

2019-04-16

Abstract excerpt

Knowledge of how transition state inhibitors bind to γ -secretase is of major importance for the design of new Alzheimer’s disease therapies. Based on the known structure of γ -secretase in complex with a fragment of the amyloid precursor protein we have generated a structural model of γ -secretase in complex with the effective L-685,458 transition state inhibitor. The predicted binding mode is in excellent agr...

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Literature Corpus work: b16c5d1b-741a-508b-b7c6-8bf066c338ea
DOI: 10.1101/611194

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