Article

Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations

2021-11-30

Abstract excerpt

Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β and γ secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides. Presenilin-1 (PS1) or presenilin-2 (PS2) pay a role of catalytic subunit of γ-secretase. Multiple familial AD (FAD) mutations in...

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Literature Corpus work: 112d5903-6944-53f9-a514-5abf2f9fa870
DOI: 10.20944/preprints202111.0564.v1

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