Article

Replication stress underlies genomic instability at CTCF/cohesin-binding sites in cancer

2023-10-27

Abstract excerpt

CCCTC-binding factor (CTCF) and cohesin play a significant role in the formation of chromatin loops and topologically associating domains (TADs), which influence gene expression and DNA replication. CTCF/cohesin-binding sites (CBSs) present at the loop anchors and TAD boundaries are frequently mutated in cancer; however, the molecular mechanisms underlying this remain unclear. Here, we investigate whether the bind...

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Literature Corpus work: 394bdfaa-ad9b-5277-a40e-2d4cb7217009
DOI: 10.1101/2023.10.24.563697

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