Article
Cohesin association to replication sites depends on rad50 and promotes fork restart.
Molecular cell - 12 Oct 2012
Tittel-Elmer Mireille, Lengronne Armelle, Davidson Marta B, Bacal Julien, François Philippe, Hohl Marcel, Petrini John H J, Pasero Philippe, Cobb Jennifer A
Abstract excerpt
The cohesin complex holds together newly replicated chromatids and is involved in diverse pathways that preserve genome integrity. We show that in budding yeast, cohesin is transiently recruited to active replication origins, and it spreads along DNA as forks progress. When DNA synthesis is impeded, cohesin accumulates at replication sites and is critical for the recovery of stalled forks. Cohesin enrichment at...
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