Article
Emerging themes in cohesin cancer biology.
Nature reviews. Cancer - 1 Sept 2020
Waldman Todd
Abstract excerpt
Mutations of the cohesin complex in human cancer were first discovered ~10 years ago. Since then, researchers worldwide have demonstrated that cohesin is among the most commonly mutated protein complexes in cancer. Inactivating mutations in genes encoding cohesin subunits are common in bladder cancers, paediatric sarcomas, leukaemias, brain tumours and other cancer types. Also in those 10 years, the prevailing...
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