Article

Transcription and replication organize cohesin-dependent chromosome loops

2020-12-16

Abstract excerpt

Genome function and stability is strictly dependent on regulated folding of chromosomes in space and time. Chromosome loop formation by the protein complex cohesin is a central feature of this multilayer organization 1 . Accumulating evidence indicates that cohesin creates loops by extruding chromosomal DNA through its ring-like structure in a process that is controlled by the cohesin loading factor Scc2 and the...

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Literature Corpus work: b6429d12-d0ed-57d7-b416-431430d351df
DOI: 10.1101/2020.12.16.423068

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