Article

Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer

2021-10-12

Abstract excerpt

Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN) and whole chromosome instability (W-CIN). Replication stress (RS), a condition of slowed or stalled DNA replication during S phase, has been linked to S-CIN, whereas defects in mitosis leading to chromosome missegregation and aneuploidy can account for W-CIN. It is well established that RS can activate additional replication...

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Literature Corpus work: c0c62aaa-2359-58ea-a1e4-d05301e1533b
DOI: 10.1101/2021.10.11.463929

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