Article

NMR solution structure and analysis of isolated S3b-S4a motif of repeat IV of the human cardiac sodium channel

2021-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Voltage-gated sodium channels are membrane proteins that play an important role in the propagation of electrical signals by mediating the rising phase of an action potential. Numerous diseases, including epilepsy, extreme pain, and certain cardiac arrhythmias have been linked to defects in these channels. The S3b-S4a helix-turn-helix motif (paddle motif) is a region of the channel that is involv...

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Literature Corpus work: 9767abb4-95d5-55ce-b175-38959331cdd2
DOI: 10.1101/2021.05.21.443843

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