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Article

The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations.

Scientific reports - 14 Mar 2018

Gardill Bernd R, Rivera-Acevedo Ricardo E, Tung Ching-Chieh, Okon Mark, McIntosh Lawrence P, Van Petegem Filip

Abstract excerpt

Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been shown to affect inactivation. A cluster of disease mutations, linked to Long-QT and Brugada syndromes, is located in a...

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Identifiers

PMID: 29540853
DOI: 10.1038/s41598-018-22713-y
PMCID: PMC5852250

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