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Article

Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2022

Huang Gaoxingyu, Wu Qiurong, Li Zhangqiang, Jin Xueqin, Huang Xiaoshuang, Wu Tong, Pan Xiaojing, Yan Nieng

Abstract excerpt

Voltage-gated sodium (Nav) channel Nav1.7 has been targeted for the development of nonaddictive pain killers. Structures of Nav1.7 in distinct functional states will offer an advanced mechanistic understanding and aid drug discovery. Here we report the cryoelectron microscopy analysis of a human Nav1.7 variant that, with 11 rationally introduced point mutations, has a markedly right-shifted activation voltage...

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Identifiers

PMID: 35878056
DOI: 10.1073/pnas.2209164119
PMCID: PMC9388133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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