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Article

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

Journal of molecular biology - 1 Nov 2013

Amador Fernando J, Kimlicka Lynn, Stathopulos Peter B, Gasmi-Seabrook Geneviève M C, Maclennan David H, Van Petegem Filip, Ikura Mitsuhiko

Abstract excerpt

Ryanodine receptors (RyRs) are large tetrameric calcium (Ca(2+)) release channels found on the sarcoplasmic reticulum that respond to dihydropyridine receptor activity through a direct conformational interaction and/or indirect Ca(2+) sensitivity, propagating sarcoplasmic reticulum luminal Ca(2+)...

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Source

Identifiers

PMID: 23978697
DOI: 10.1016/j.jmb.2013.08.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23978697-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.PMID 23978697Read ↗

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