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Article

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic Modulation

2025-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Chloride Intracellular Channel 1 (CLIC1) is a metamorphic protein capable of transitioning from a soluble cytoplasmic state to a membrane-bound chloride channel. This conformational shift, crucial for physiological processes such as cell volume regulation, electrical excitability, and angiogenesis, is linked to pathological conditions including malignancies and cardiovascular diseases. Despite i...

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Literature Corpus work
41f8cca4-79c7-54c4-8798-911aa5c3fbeb
DOI
10.1101/2025.01.19.633805
Open publication

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Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic ModulationDOI 10.1101/2025.01.19.633805
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