Article

Structural dynamics of the intrinsically disordered linker region of cardiac troponin T

2024-05-31

Abstract excerpt

<h4>ABSTRACT</h4> The cardiac troponin complex, composed of troponins I, T, and C, plays a central role in regulating the calcium-dependent interactions between myosin and the thin filament. Mutations in troponin can cause cardiomyopathies; however, it is still a major challenge to connect how changes in sequence affect troponin’s function. Recent high-resolution structures of the thin filament revealed critical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65d62a5e-5a5d-5d88-ae0c-2c4d786af352
DOI: 10.1101/2024.05.30.596451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural dynamics of the intrinsically disordered linker region of cardiac troponin TDOI 10.1101/2024.05.30.596451Read

Resolving the structure and dynamics of the disordered C terminus of human cardiac troponin T and effects of cardiomyopathic mutations.Semantic proximity Read

Troponins, intrinsic disorder, and cardiomyopathy.Semantic proximity Read

Role of cardiac troponin I carboxy terminal mobile domain and linker sequence in regulating cardiac contraction.Semantic proximity Read

Investigating cardiomyopathies with atomistic simulations of cardiac TroponinSemantic proximity Read

Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin.Semantic proximity Read

Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Semantic proximity Read

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.Semantic proximity Read

CONSERVED INTERACTIONS IN CARDIAC SYNTHETIC THICK FILAMENTS DIFFERENTLY AFFECT MYOSIN SUPER-RELAXED STATE IN HEALTHY, DISEASE AND MAVACAMTEN-TREATED MODELSSemantic proximity Read

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C.Semantic proximity Read

Folding and function of the troponin tail domain. Effects of cardiomyopathic troponin T mutations.Semantic proximity Read

Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers.Semantic proximity Read

Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling.Semantic proximity Read