Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4.

PloS one - 2 Nov 2009

Ma Zhongming, Kong Jun, Kallen Roland G

Abstract excerpt

Much data, including crystallographic, support structural models of sodium and potassium channels consisting of S1-S4 transmembrane segments (the "voltage-sensing domain") clustered around a central pore-forming region (S5-S6 segments and the intervening loop). Voltage gated sodium channels have four non-identical domains which differentiates them from the homotetrameric potassium channels that form the basis for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Fourier Analysis
Share to Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NAV1.4 Voltage-Gated Sodium Channel

Share to Potassium

Share to Potassium Channels

Share to Sodium Channels

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 19881885
DOI: 10.1371/journal.pone.0007674
PMCID: PMC2766034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4.PMID 19881885Read ↗

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels.Semantic proximity Read ↗

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel.Semantic proximity Read ↗

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.Semantic proximity Read ↗

Gating Pore Currents in Sodium Channels.Semantic proximity Read ↗

Role of hydrophobic residues in the voltage sensors of the voltage-gated sodium channel.Semantic proximity Read ↗

Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.Semantic proximity Read ↗

Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment.Semantic proximity Read ↗

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.Semantic proximity Read ↗

Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.Semantic proximity Read ↗

Molecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains.Semantic proximity Read ↗

The complete structure of an activated open sodium channel.Semantic proximity Read ↗

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.