Article
Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.
Science (New York, N.Y.) - 19 Oct 2018
Pan Xiaojing, Li Zhangqiang, Zhou Qiang, Shen Huaizong, Wu Kun, Huang Xiaoshuang, Chen Jiaofeng, Zhang Juanrong, Zhu Xuechen, Lei Jianlin, Xiong Wei, Gong Haipeng, Xiao Bailong, Yan Nieng
Abstract excerpt
Voltage-gated sodium (Nav) channels, which are responsible for action potential generation, are implicated in many human diseases. Despite decades of rigorous characterization, the lack of a structure of any human Nav channel has hampered mechanistic understanding. Here, we report the cryo-electron microscopy structure of the human Nav1.4-β1 complex at 3.2-Å resolution. Accurate model building was made for the...
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