Article

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease

2021-10-16

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) is one of the foremost neurodegenerative diseases, characterized by beta-amyloid (Aβ) plaques and significant progressive memory loss. In AD, astrocytes are known to take up and clear Aβ plaques. However, how Aβ induces pathogenesis and memory impairment in AD remains elusive. We report that normal astrocytes show non-cyclic urea metabolism, whereas Aβ-treated astrocytes...

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Literature Corpus work: 975a09e3-afda-5d10-b966-60d315114217
DOI: 10.1101/2021.10.15.464517

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