Article

Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway

2023-01-13

Abstract excerpt

<h4>ABSTRACT</h4> GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the CNS. In astrocytes, GABA is synthesized by degradation of putrescine by monoamine oxidase B (MAO-B), a process which is known to mediate tonic inhibition of neuronal excitability. This astrocytic tonic GABA and related enzymes are also reported to be involved in memory impairment in Alzheimer’s Disease, and therefore ar...

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Literature Corpus work: abe414c2-95ce-54d0-b4f4-4afee4fdc3e5
DOI: 10.1101/2023.01.11.523573

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