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Article

Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer's disease.

Nature communications - 7 May 2024

Chen Tianlu, Pan Fengfeng, Huang Qi, Xie Guoxiang, Chao Xiaowen, Wu Lirong, Wang Jie, Cui Liang, Sun Tao, Li Mengci, Wang Ying, Guan Yihui, Zheng Xiaojiao, Ren Zhenxing, Guo Yuhuai, Wang Lu, Zhou Kejun, Zhao Aihua, Guo Qihao, Xie Fang, Jia Wei

Abstract excerpt

The metabolic implications in Alzheimer's disease (AD) remain poorly understood. Here, we conducted a metabolomics study on a moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile acids, branch-chain amino acids (BCAAs), and glutamate-related features exhibited strong correlations with cognitive impairment, clinical stage, and brain amyloid-β deposition (n = 421). These features...

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Identifiers

PMID: 38714706
DOI: 10.1038/s41467-024-47897-y
PMCID: PMC11076546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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