Article

ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity

2026-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Aging is the strongest risk factor for neurodegeneration, yet how the human brain ages remains poorly understood. Loss-of-function (LOF) variants in ATP13A2 cause severe juvenile-onset Parkinson’s disease, providing a window into the mechanisms that accelerate age-related neurodegeneration. ATP13A2-LOF causes lysosomal polyamine sequestration, but how this promotes pathogenesis remains unclear....

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Literature Corpus work: ee152c1b-a656-54ac-96ba-d9309f0abaed
DOI: 10.64898/2026.04.02.716164

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