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Article

Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes.

Journal of neurochemistry - 1 Jan 2025

Elsworthy Richard J, Finelli Mattea J, Aqattan Sarah, Dunleavy Connor, King Marianne, Ludlam Adele, Tarczyluk Marta A, Allen Sophie L, Prosser Sophie, Chen Rui, Jarquin Sandra Martinez, Kim Dong H, Brown James, Parri H R, Aldred Sarah, Hill Eric J

Abstract excerpt

Altered energy metabolism in Alzheimer's disease (AD) is a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and are implicated in multiple neurodegenerative diseases. Although numerous studies have investigated global changes in brain metabolism, redox status, gene expression and epigenetic markers in AD, the intricate interplay...

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PMID: 39696767
DOI: 10.1111/jnc.16267
PMCID: PMC11655965

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