Article

“Glutaminolysis Fuels Reactive Astrocytes, Exacerbating Amyloid Pathology in Alzheimer’s Disease”

2025-06-15

Abstract excerpt

Amyloid-β (Aβ) plaques with progressively increasing reactive astrocytes characterize Alzheimer’s disease (AD). Reactive astrocytes are regulated by cellular and molecular mechanisms that are known to progress Aβ pathology. However, the metabolic adaptation and metabolites required to fuel these molecular changes in reactive astrocytes remain unknown. Using human AD samples, in vivo amyloid mouse models, and in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a470c7a6-e47b-5628-bf1d-a702a68d29f2
DOI: 10.1101/2025.06.12.658977

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

“Glutaminolysis Fuels Reactive Astrocytes, Exacerbating Amyloid Pathology in Alzheimer’s Disease”DOI 10.1101/2025.06.12.658977Read

Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytesSemantic proximity Read

Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes.Semantic proximity Read

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s diseaseSemantic proximity Read

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.Semantic proximity Read

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein NeurodegenerationSemantic proximity Read

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologiesSemantic proximity Read

Glutamate-Glutamine Homeostasis is Perturbed in Neurons and Astrocytes derived from Patient iPSC Models of Frontotemporal DementiaSemantic proximity Read

Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease.Semantic proximity Read

Metabolic Signaling Cascades Prompted by Glutaminolysis in CancerSemantic proximity Read

Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization StudySemantic proximity Read

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survivalSemantic proximity Read

Hyperglycemia Stimulates the Irreversible Catabolism of Branched-Chain Amino Acids and Generation of Ketone Bodies by Cultured Human AstrocytesSemantic proximity Read