Article

Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytes

2023-08-24

Abstract excerpt

Altered energy metabolism in Alzheimer’s disease (AD) is considered a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and are increasingly implicated in multiple neurodegenerative diseases. We report that astrocytes differentiated from early onset familial Alzheimer’s disease (fAD) patients or control cells treated with Amyloid...

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Literature Corpus work: 4758f4cd-4903-5276-ab06-00d9a3343d18
DOI: 10.1101/2023.08.23.554346

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