Article

Polyamine biosynthesis dysregulation in Alzheimer’s disease and Down syndrome cellular models

2025-02-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Individuals with Down Syndrome (DS) frequently develop early onset Alzheimer’s disease (AD) with pathological hallmarks closely resembling AD due to several triplicated genes on chromosome 21. Polyamines are small, organic molecules that play a pivotal role for growth and differentiation, and a dysregulation of polyamine pathways is implicated in AD pathology. However, their...

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Literature Corpus work: 62b1900f-6992-5832-a523-23797d73ea06
DOI: 10.1101/2025.01.31.635912

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