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NAD <sup>+</sup> - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal models

2024-10-28

Abstract excerpt

Aberrant alternative splicing (ASEs) is an aging hallmark to Alzheimer’s Disease (AD). Although NAD + and related metabolites can slow down AD, NAD + on ASEs in AD remain unclear. Mouse transcriptomic data revealed NR-induced ASEs, focusing on the Eva1-C locus. AI-based algorithms predicted EVA1-C protein structures and protein-protein interactions. AD postmortem brain samples and tauopathy models including tran...

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Literature Corpus work
91a0fb79-ee88-51b4-9392-17633c47c57b
DOI
10.1101/2024.10.27.620478
Open publication

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NAD <sup>+</sup> - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal modelsDOI 10.1101/2024.10.27.620478
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