Article

Silencer variants are key drivers of gene upregulation in Alzheimer’s disease

2025-04-08

Abstract excerpt

Alzheimer’s disease (AD), particularly late-onset AD, stands as the most prevalent neurodegenerative disorder globally. Owing to its substantial heritability, genetic studies have emerged as indispensable for elucidating genes and biological pathways driving AD onset and progression. However, genetic and molecular mechanisms underlying AD remain poorly defined, largely due to the pronounced heterogeneity of AD and...

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Literature Corpus work: afb9180f-c68d-5b2a-aa8e-c7b5ecdeeb77
DOI: 10.1101/2025.04.07.25325386

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