Article

Protective Role of Galectin-3 in Prion Disease Through Regulation of Microglial PrP <sup>Sc</sup> Uptake

2026-06-16

Abstract excerpt

Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways regulating microglial responses during disease progression remain incompletely understood. Galectin-3 (Gal3), a β-galactoside-binding lectin associated with reactive microglia in multiple neurodegenerative disorders, has been implicated in phagocytosis, inflammatory signaling, and lysosomal homeostasis. H...

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Literature Corpus work: 96cb1fe2-20f6-5e3a-8882-e5bab0d5f037
DOI: 10.64898/2026.06.11.731738

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