Article

Galectin-3 drives neuroinflammatory amyloid remodeling by stabilizing intermediate Aβ species and altering lysosomal processing

2025-03-17

Abstract excerpt

Neuroinflammation is a hallmark of Alzheimer’s disease (AD), yet the molecular mediators driving microglial dysfunction and neurotoxicity remain poorly understood. Here, we identify Galectin-3 (Gal3) as a central regulator of plaque-associated microglial responses, linking amyloid-beta (Aβ) aggregation, lysosomal function and plaque-associated neuritic damage. Using postmortem brain tissue from AD patients, we dem...

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Identifiers and source

Literature Corpus work: fc208275-a544-5ea6-b002-879ab17dd1e4
DOI: 10.1101/2025.03.17.643790

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