Article

Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease

2018-12-04

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, intraneuronal tau neurofibrillary tangles and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in A...

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Literature Corpus work: a60ea32c-cc8e-5869-96ef-91de3808e1f6
DOI: 10.1101/477927

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