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Article

Microglia in prion diseases.

The Journal of clinical investigation - 1 Sept 2017

Aguzzi Adriano, Zhu Caihong

Abstract excerpt

Prion diseases are a group of progressive and fatal neurodegenerative disorders characterized by deposition of scrapie prion protein (PrPSc) in the CNS. This deposition is accompanied by neuronal loss, spongiform change, astrogliosis, and conspicuous microglial activation. Here, we argue that microglia play an overall neuroprotective role in prion pathogenesis. Several microglia-related molecules, such as...

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Identifiers

PMID: 28714865
DOI: 10.1172/JCI90605
PMCID: PMC5669569

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