Article

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

2024-07-31

Abstract excerpt

<h4>Summary</h4> Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1 + microglia mutant clones across the brain of LCH and ECD patients with and without neurological symptoms, associated with microgliosis, reactive astrocytosis, and neur...

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Literature Corpus work: 829e83b1-43aa-5b4e-ab52-d507838ff917
DOI: 10.1101/2024.07.30.605867

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