Article

Regional patterns of neurodegeneration in a mouse model of proteinopathy

2025-08-18

Abstract excerpt

<h4>ABSTRACT</h4> The aggregation of misfolded proteins is a hallmark of many neurodegenerative diseases, suggesting shared pathological mechanisms. However, the pathways by which protein misfolding in these proteinopathies lead to neuronal death remain unclear. Proteinopathies can be modelled in transgenic animals by expressing disease-causing mutations that promote protein aggregation, or in wild-type animals b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37805d6a-6863-50ce-a42b-ca1cf02e0f45
DOI: 10.1101/2025.08.17.670564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regional patterns of neurodegeneration in a mouse model of proteinopathyDOI 10.1101/2025.08.17.670564Read

Current concepts and molecular pathology of neurodegenerative diseasesSemantic proximity Read

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic NeurodegenerationSemantic proximity Read

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer’s Knock-in Mice Require Cellular Prion ProteinSemantic proximity Read

Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases.Semantic proximity Read

Loss of region-specific glial homeostatic signature in prion diseasesSemantic proximity Read

Common mouse models of tauopathy reflect early but not late human diseaseSemantic proximity Read

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer’s DiseaseSemantic proximity Read

Loss of region-specific glial homeostatic signature in prion diseasesSemantic proximity Read

Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion DiseaseSemantic proximity Read

Signatures of glial activity can be detected in the CSF proteomeSemantic proximity Read

Propagation of pathology through brain networks in neurodegenerative diseases: from molecules to clinical phenotypes.Semantic proximity Read

Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype.Semantic proximity Read