Article

Galectin-3 drives tau-associated neuroinflammation, white matter degeneration and proteomic dysregulation

2026-07-10

Abstract excerpt

Tau pathology is a central driver of neurodegeneration, yet the molecular mechanisms linking tau accumulation to neuroinflammation, metabolic failure, and white matter degeneration remain incompletely understood. Galectin-3 (Gal3) is an inflammation-associated lectin expressed by activated microglia and has been implicated in neurodegenerative disease progression. Here, we investigated whether Gal3 modulates tau-d...

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Literature Corpus work: 09a36e62-02ee-5591-ad12-6827a533b3f2
DOI: 10.64898/2026.07.07.736964

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