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Article

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.

Molecular biology of the cell - 1 Jun 2001

Shareef M M, King C, Damaj M, Badagu R, Huang D W, Kellum R

Abstract excerpt

Heterochromatin protein 1 (HP1) is a conserved component of the highly compact chromatin of higher eukaryotic centromeres and telomeres. Cytogenetic experiments in Drosophila have shown that HP1 localization into this chromatin is perturbed in mutants for the origin recognition complex (ORC) 2 subunit. ORC has a multisubunit DNA-binding activity that binds origins of DNA replication where it is required for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11408576
DOI: 10.1091/mbc.12.6.1671
PMCID: PMC37332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.PMID 11408576Read ↗

Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation.Semantic proximity Read ↗

Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins.Semantic proximity Read ↗

Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution.Semantic proximity Read ↗

HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.Semantic proximity Read ↗

Orc mutants arrest in metaphase with abnormally condensed chromosomes.Semantic proximity Read ↗

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repairSemantic proximity Read ↗

Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.Semantic proximity Read ↗

Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain.Semantic proximity Read ↗

HP1 is distributed within distinct chromatin domains at Drosophila telomeres.Semantic proximity Read ↗

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase.Semantic proximity Read ↗

Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.Semantic proximity Read ↗

Heterochromatin protein 1 is recruited to various types of DNA damage.Semantic proximity Read ↗

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